InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ncf4

Summary

InnateDB Protein

IDBP-158766.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ncf4

Protein Name

neutrophil cytosolic factor 4

Synonyms

AI451400; p40phox;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000094084

InnateDB Gene

IDBG-158764 (Ncf4)

Protein Structure

UniProt Annotation

Function

Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. {ECO:0000269PubMed:8995189}.

Subcellular Localization

Cytoplasm, cytosol. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016176	superoxide-generating NADPH oxidase activator activity
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0035091	phosphatidylinositol binding