Mus musculus Gene: Ncf4
Summary
InnateDB Gene IDBG-158764.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncf4
Gene Name neutrophil cytosolic factor 4
Synonyms AI451400; p40phox;
Species Mus musculus
Ensembl Gene ENSMUSG00000071715
Encoded Proteins
neutrophil cytosolic factor 4
neutrophil cytosolic factor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100365:
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78244801-78262580
Strand Forward strand
Band E1
Transcripts
ENSMUST00000096357 ENSMUSP00000094084
ENSMUST00000133618 ENSMUSP00000121191
ENSMUST00000147303
ENSMUST00000126028
ENSMUST00000146147
ENSMUST00000148646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0043085 positive regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0043020 NADPH oxidase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Signaling by VEGF pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Antigen processing-Cross presentation pathway
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Adaptive Immune System pathway
Signal Transduction pathway
KEGG
Phagosome pathway
Osteoclast differentiation pathway
Leukocyte transendothelial migration pathway
Leishmaniasis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Signaling by VEGF pathway
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Signal Transduction pathway
Antigen processing-Cross presentation pathway
Phagosomal maturation (early endosomal stage) pathway
Adaptive Immune System pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Class I MHC mediated antigen processing & presentation pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
KEGG
Phagosome pathway
Osteoclast differentiation pathway
Leukocyte transendothelial migration pathway
Leishmaniasis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P97369
TrEMBL Q3TC82
UniProt Splice Variant
Entrez Gene 17972
UniGene Mm.2068
RefSeq NM_008677 XM_006520564 XM_006520565
OMIM
CCDS CCDS27610
HPRD
IMGT
MGI ID MGI:109186
MGI Symbol Ncf4
EMBL AB002665 AK150510 AK170854 AK171315 AL589692 BC025517 CH466545 U59488
GenPept AAC53122 AAH25517 BAA25651 BAE29623 BAE42075 BAE42387 CAP19156 EDL29666
RNA Seq Atlas 17972