InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ncf4

Summary

InnateDB Gene

IDBG-158764.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ncf4

Gene Name

neutrophil cytosolic factor 4

Synonyms

AI451400; p40phox

Species

Mus musculus

Ensembl Gene

ENSMUSG00000071715

Encoded Proteins

IDBP-158766

neutrophil cytosolic factor 4

IDBP-538200

neutrophil cytosolic factor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100365:
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:78244801-78262580

Strand

Forward strand

Band

Transcripts

ENSMUST00000096357	ENSMUSP00000094084
ENSMUST00000133618	ENSMUSP00000121191
ENSMUST00000147303
ENSMUST00000126028
ENSMUST00000146147
ENSMUST00000148646

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016176	superoxide-generating NADPH oxidase activator activity
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0035091	phosphatidylinositol binding