InnateDB Protein
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IDBP-159029.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nr0b1
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Protein Name
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nuclear receptor subfamily 0, group B, member 1
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Synonyms
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Ahc; Ahch; AHX; DAX-1; Dax1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000026036
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InnateDB Gene
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IDBG-159027 (Nr0b1)
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Protein Structure
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Function |
Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in adult cerebral cortex, spinal cord, thymus, heart, lung, ovary, testis, adrenal gland, hypothalamus, spleen and kidney. {ECO:0000269PubMed:8756567}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
6
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1352460
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InterPro |
IPR000536
Nuclear hormone receptor, ligand-binding, core
IPR001723
Steroid hormone receptor
IPR008946
Nuclear hormone receptor, ligand-binding
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PFAM |
PF00104
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PRINTS |
PR00398
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PIRSF |
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SMART |
SM00430
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TIGRFAMs |
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Modification |
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SwissProt |
Q61066
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PhosphoSite |
PhosphoSite-Q61066
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TrEMBL |
Q53ZY9
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UniProt Splice Variant |
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Entrez Gene |
11614
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UniGene |
Mm.5180
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RefSeq |
NP_031456
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MGI ID |
3F5C
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MGI Symbol |
Nr0b1
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OMIM |
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CCDS |
CCDS30260
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HPRD |
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IMGT |
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EMBL |
AK141239
AY227358
CH466576
S83178
S83180
U41568
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GenPept |
AAB46875
AAC52920
AAO47789
BAE24608
EDL29149
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