Version 5.4
Mus musculus Gene: Nr0b1
Summary
InnateDB Gene IDBG-159027.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nr0b1
Gene Name nuclear receptor subfamily 0, group B, member 1
Synonyms Ahc; Ahch; AHX; DAX-1; Dax1
Species Mus musculus
Ensembl Gene ENSMUSG00000025056
Encoded Proteins
IDBP-159029
nuclear receptor subfamily 0, group B, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169297:
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:86191764-86195947
Strand Forward strand
Band C1
Transcripts
ENSMUST00000026036 ENSMUSP00000026036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 21 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
GO:0032448 DNA hairpin binding
GO:0035258 steroid hormone receptor binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0050682 AF-2 domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006694 steroid biosynthetic process
GO:0007283 spermatogenesis
GO:0007530 sex determination
GO:0008104 protein localization
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0030154 cell differentiation
GO:0030238 male sex determination
GO:0030325 adrenal gland development
GO:0030522 intracellular receptor signaling pathway
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033327 Leydig cell differentiation
GO:0035902 response to immobilization stress
GO:0043401 steroid hormone mediated signaling pathway
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045596 negative regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060008 Sertoli cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042788 polysomal ribosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169297
View Gene Order
ENSBTAG00000015532
Not yet available
Pathways
NETPATH
REACTOME
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_233572
Gene Expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
erb_genomic_pathway
Validated nuclear estrogen receptor beta network
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt Q61066
TrEMBL Q53ZY9
UniProt Splice Variant
Entrez Gene 11614
UniGene Mm.5180
RefSeq NM_007430
OMIM
CCDS CCDS30260
HPRD
IMGT
MGI ID MGI:1352460
MGI Symbol Nr0b1
EMBL AK141239 AY227358 CH466576 S83178 S83180 U41568
GenPept AAB46875 AAC52920 AAO47789 BAE24608 EDL29149
RNA Seq Atlas 11614

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca