InnateDB Protein
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IDBP-159353.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Scn4b
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Protein Name
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sodium channel, type IV, beta
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000062507
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InnateDB Gene
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IDBG-159351 (Scn4b)
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Protein Structure
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Function |
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0005248
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voltage-gated sodium channel activity
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GO:0005515
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protein binding
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GO:0017080
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sodium channel regulator activity
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GO:0044325
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ion channel binding
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GO:0086006
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voltage-gated sodium channel activity involved in cardiac muscle cell action potential
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Biological Process |
GO:0006814
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sodium ion transport
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GO:0010765
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positive regulation of sodium ion transport
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GO:0035725
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sodium ion transmembrane transport
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GO:0060048
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cardiac muscle contraction
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GO:0060307
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regulation of ventricular cardiac muscle cell membrane repolarization
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GO:0086002
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cardiac muscle cell action potential involved in contraction
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GO:0086012
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membrane depolarization during cardiac muscle cell action potential
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GO:0086067
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AV node cell to bundle of His cell communication
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GO:0086091
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regulation of heart rate by cardiac conduction
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GO:2000649
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regulation of sodium ion transmembrane transporter activity
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Cellular Component |
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PDB ID |
MGI:2687406
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InterPro |
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
IPR013106
Immunoglobulin V-set domain
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PFAM |
PF07686
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PRINTS |
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
Q7M729
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PhosphoSite |
PhosphoSite-Q7M729
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TrEMBL |
Q1MXF9
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UniProt Splice Variant |
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Entrez Gene |
399548
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UniGene |
Mm.335112
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RefSeq |
NP_001013408
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MGI ID |
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MGI Symbol |
Scn4b
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OMIM |
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CCDS |
CCDS23130
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HPRD |
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IMGT |
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EMBL |
AB118946
AC122305
AC122504
AY669079
BC139399
BC139400
BK001031
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GenPept |
AAI39400
AAI39401
AAU05394
BAE93689
DAA01205
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