Version 5.4
Mus musculus Gene: Scn4b
Summary
InnateDB Gene IDBG-159351.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scn4b
Gene Name sodium channel, type IV, beta
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000046480
Encoded Proteins
IDBP-159353
sodium channel, type IV, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177098:
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:45138437-45154152
Strand Forward strand
Band A5.2
Transcripts
ENSMUST00000060125 ENSMUSP00000062507
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005248 voltage-gated sodium channel activity
GO:0005515 protein binding
GO:0017080 sodium channel regulator activity
GO:0044325 ion channel binding
GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential
Biological Process
GO:0006814 sodium ion transport
GO:0010765 positive regulation of sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0060048 cardiac muscle contraction
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086067 AV node cell to bundle of His cell communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:2000649 regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0014704 intercalated disc
GO:0031226 intrinsic component of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000177098
View Gene Order
ENSBTAG00000039340
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q7M729
TrEMBL Q1MXF9
UniProt Splice Variant
Entrez Gene 399548
UniGene Mm.335112
RefSeq NM_001013390
OMIM
CCDS CCDS23130
HPRD
IMGT
MGI ID MGI:2687406
MGI Symbol Scn4b
EMBL AB118946 AC122305 AC122504 AY669079 BC139399 BC139400 BK001031
GenPept AAI39400 AAI39401 AAU05394 BAE93689 DAA01205
RNA Seq Atlas 399548

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca