InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ints10

Summary

InnateDB Protein

IDBP-159406.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ints10

Protein Name

integrator complex subunit 10

Synonyms

4921521J11Rik; AI462004;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069908

InnateDB Gene

IDBG-159402 (Ints10)

Protein Structure

UniProt Annotation

Function

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0016180

snRNA processing

Cellular Component

GO:0005737	cytoplasm
GO:0032039	integrator complex

Protein Structure and Domains

PDB ID

MGI:1918135

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K2A7

PhosphoSite

PhosphoSite-Q8K2A7

TrEMBL

E9Q361

UniProt Splice Variant

Entrez Gene

70885

UniGene

Mm.474073

RefSeq

XP_006509806

MGI ID

MGI Symbol

Ints10

OMIM

CCDS

HPRD

IMGT

EMBL

AC123813 AK014939 AK034498 AK040574 BC031923

GenPept

AAH31923 BAB29629 BAC28731 BAC30632