InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndufb4

Summary

InnateDB Protein

IDBP-159661.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufb4

Protein Name

NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4

Synonyms

0610006N12Rik; 1300010H20Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023514

InnateDB Gene

IDBG-159659 (Ndufb4)

Protein Structure

UniProt Annotation

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008137	NADH dehydrogenase (ubiquinone) activity

Biological Process

GO:0006979	response to oxidative stress
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005747	mitochondrial respiratory chain complex I
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome