InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fxyd2

Summary

InnateDB Protein

IDBP-159674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fxyd2

Protein Name

FXYD domain-containing ion transport regulator 2

Synonyms

Atp1g1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035429

InnateDB Gene

IDBG-159670 (Fxyd2)

Protein Structure

UniProt Annotation

Function

May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highest levels expressed in the kidney and spleen. Restricted to the basolateral membrane in renal epithelial cells and varies in its level of expression along the nephron.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0035725	sodium ion transmembrane transport
GO:0042127	regulation of cell proliferation

Cellular Component

GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome