InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fxyd2

Summary

InnateDB Gene

IDBG-159670.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fxyd2

Gene Name

FXYD domain-containing ion transport regulator 2

Synonyms

Atp1g1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059412

Encoded Proteins

IDBP-159674

FXYD domain-containing ion transport regulator 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq, Sep 2009]
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme\'s activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:45403138-45410278

Strand

Forward strand

Band

A5.2

Transcripts

ENSMUST00000041005

ENSMUSP00000035429

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0035725	sodium ion transmembrane transport
GO:0042127	regulation of cell proliferation

Cellular Component

GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome