Mus musculus Gene: Fxyd2
Summary
InnateDB Gene IDBG-159670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fxyd2
Gene Name FXYD domain-containing ion transport regulator 2
Synonyms Atp1g1;
Species Mus musculus
Ensembl Gene ENSMUSG00000059412
Encoded Proteins
FXYD domain-containing ion transport regulator 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq, Sep 2009]
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme\'s activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:45403138-45410278
Strand Forward strand
Band A5.2
Transcripts
ENSMUST00000041005 ENSMUSP00000035429
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005391 sodium:potassium-exchanging ATPase activity
GO:0005515 protein binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0042127 regulation of cell proliferation
Cellular Component
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Ion channel transport pathway
Transmembrane transport of small molecules pathway
Ion transport by P-type ATPases pathway
KEGG
Cardiac muscle contraction pathway
Aldosterone-regulated sodium reabsorption pathway
Proximal tubule bicarbonate reclamation pathway
Salivary secretion pathway
Pancreatic secretion pathway
Carbohydrate digestion and absorption pathway
Protein digestion and absorption pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Ion transport by P-type ATPases pathway
Ion channel transport pathway
KEGG
Cardiac muscle contraction pathway
Aldosterone-regulated sodium reabsorption pathway
Proximal tubule bicarbonate reclamation pathway
Salivary secretion pathway
Pancreatic secretion pathway
Carbohydrate digestion and absorption pathway
Protein digestion and absorption pathway
Bile secretion pathway
INOH
PID BIOCARTA
Oxidative stress induced gene expression via nrf2 [Biocarta view]
PID NCI
Cross-References
SwissProt Q04646
TrEMBL Q6ITT1
UniProt Splice Variant
Entrez Gene 11936
UniGene
RefSeq NM_052823 XM_006509958
OMIM
CCDS CCDS23134
HPRD
IMGT
MGI ID MGI:1195260
MGI Symbol Fxyd2
EMBL AK002215 AY035583 AY626244 BC024614 CH466522 X70060
GenPept AAH24614 AAK62036 AAK62037 AAK62038 AAT45732 BAC24981 CAA49664 EDL25651
RNA Seq Atlas 11936