InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp2f2

Summary

InnateDB Protein

IDBP-159853.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp2f2

Protein Name

cytochrome P450, family 2, subfamily f, polypeptide 2

Synonyms

Cyp2f;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003100

InnateDB Gene

IDBG-159851 (Cyp2f2)

Protein Structure

UniProt Annotation

Function

Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl- 1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung. {ECO:0000269PubMed:1742282, ECO:0000269PubMed:1981702}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Clara cells in lung and liver. {ECO:0000269PubMed:1742282, ECO:0000269PubMed:1981702}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0020037	heme binding

Biological Process

GO:0009636	response to toxic substance
GO:0018931	naphthalene metabolic process
GO:0018979	trichloroethylene metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:88608

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR020469 Cytochrome P450, CYP2 family

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00463
PR00465
PR01957

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P33267