Version 5.4
Mus musculus Protein: Snrpa
Summary
InnateDB Protein IDBP-160105.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Snrpa
Protein Name small nuclear ribonucleoprotein polypeptide A
Synonyms C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A;
Species Mus musculus
Ensembl Protein ENSMUSP00000079228
InnateDB Gene IDBG-160103 (Snrpa)
Protein Structure
UniProt Annotation
Function Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 57 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0017069 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
Cellular Component
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
Protein Structure and Domains
PDB ID MGI:1855690
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62189
PhosphoSite PhosphoSite-Q62189
TrEMBL D3Z0S6
UniProt Splice Variant
Entrez Gene 53607
UniGene Mm.435544
RefSeq NP_056597
MGI ID
MGI Symbol Snrpa
OMIM
CCDS CCDS21014
HPRD
IMGT
EMBL AC157553 AC157561 BC003229 BC094006 BC096648 L15447
GenPept AAC37611 AAH03229 AAH94006 AAH96648

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca