InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psip1

Summary

InnateDB Protein

IDBP-160132.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psip1

Protein Name

PC4 and SFRS1 interacting protein 1

Synonyms

AA408851; AU015605; Dfs70; Ledgfa; Ledgfb; Psip2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030207

InnateDB Gene

IDBG-160130 (Psip1)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0033613	activating transcription factor binding
GO:0044822	poly(A) RNA binding
GO:0097100	supercoiled DNA binding

Biological Process

GO:0000395	mRNA 5'-splice site recognition
GO:0006351	transcription, DNA-templated
GO:0006979	response to oxidative stress
GO:0009408	response to heat
GO:0045944	positive regulation of transcription from RNA polymerase II promoter