InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lgals1

Summary

InnateDB Protein

IDBP-160343.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lgals1

Protein Name

lectin, galactose binding, soluble 1

Synonyms

AA410090; Gal-1; Galbp; galectin-1; L-14.5; L14; Lect14;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086795

InnateDB Gene

IDBG-160341 (Lgals1)

Protein Structure

UniProt Annotation

Function

May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Strong inducer of T-cell apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005534	galactose binding
GO:0016936	galactoside binding
GO:0030246	carbohydrate binding
GO:0030395	lactose binding
GO:0042803	protein homodimerization activity
GO:0043236	laminin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002317	plasma cell differentiation
GO:0006915	apoptotic process
GO:0007157	heterophilic cell-cell adhesion
GO:0007165	signal transduction
GO:0010812	negative regulation of cell-substrate adhesion
GO:0010977	negative regulation of neuron projection development
GO:0031295	T cell costimulation
GO:0033555	multicellular organismal response to stress
GO:0034120	positive regulation of erythrocyte aggregation
GO:0042493	response to drug
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045445	myoblast differentiation
GO:0048678	response to axon injury
GO:0071333	cellular response to glucose stimulus
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome