InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbp1

Summary

InnateDB Protein

IDBP-160650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbp1

Protein Name

fructose bisphosphatase 1

Synonyms

Fbp-2; Fbp2; Fbp3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090564

InnateDB Gene

IDBG-160648 (Fbp1)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269PubMed:16497803, ECO:0000269PubMed:18375435, ECO:0000269PubMed:20719858}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in pancreatic beta-cell lines MIN6 and beta-TC and in liver (at protein level). Preferentially expressed in liver, with lower levels detected in pancreatic islets and intestine, and very low levels in blood, muscle, brain and spleen. {ECO:0000269PubMed:11250076, ECO:0000269PubMed:16497803, ECO:0000269PubMed:18375435, ECO:0000269PubMed:20719858}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016208	AMP binding
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578	phosphoric ester hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0048029	monosaccharide binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006094	gluconeogenesis
GO:0006111	regulation of gluconeogenesis
GO:0016311	dephosphorylation
GO:0030308	negative regulation of cell growth
GO:0035690	cellular response to drug
GO:0045820	negative regulation of glycolytic process
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051289	protein homotetramerization
GO:0071286	cellular response to magnesium ion

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95492

InterPro

IPR000146 Fructose-1,6-bisphosphatase class 1/Sedoheputulose-1,7-bisphosphatase
IPR023079 Sedoheptulose-1,7-bisphosphatase
IPR028343 Fructose-1,6-bisphosphatase

PFAM

PF00316

PRINTS

PR01958
PR00115

PIRSF

PIRSF000904
PIRSF500210

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt