Mus musculus Gene: Fbp1
Summary
InnateDB Gene IDBG-160648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbp1
Gene Name fructose bisphosphatase 1
Synonyms Fbp-2; Fbp2; Fbp3;
Species Mus musculus
Ensembl Gene ENSMUSG00000069805
Encoded Proteins
fructose bisphosphatase 1
fructose bisphosphatase 1
fructose bisphosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165140:
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:62864753-62888282
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000092888 ENSMUSP00000090564
ENSMUST00000150013 ENSMUSP00000117146
ENSMUST00000134814 ENSMUSP00000115703
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016208 AMP binding
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0006111 regulation of gluconeogenesis
GO:0016311 dephosphorylation
GO:0030308 negative regulation of cell growth
GO:0035690 cellular response to drug
GO:0045820 negative regulation of glycolytic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0051289 protein homotetramerization
GO:0071286 cellular response to magnesium ion
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
Glucose metabolism pathway
Metabolism pathway
Gluconeogenesis pathway
Glycogen storage diseases pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
Insulin signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Gluconeogenesis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Metabolism of carbohydrates pathway
Myoclonic epilepsy of Lafora pathway
Gluconeogenesis pathway
Glycogen storage diseases pathway
Glucose metabolism pathway
Metabolism pathway
Disease pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
Insulin signaling pathway pathway
INOH
Pentose phosphate cycle pathway
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9QXD6
TrEMBL E9Q0T7 Q9JHT6 Q9JHT7 Q9JHT8 Q9QXA8 Q9QXA9 Q9QXB0 Q9QXB1 Q9QXB2 Q9QXB3 Q9QXC2 Q9QXC3 Q9QXC4 Q9QXC5
UniProt Splice Variant
Entrez Gene 14121
UniGene Mm.423078
RefSeq NM_019395
OMIM
CCDS CCDS26590
HPRD
IMGT
MGI ID MGI:95492
MGI Symbol Fbp1
EMBL AC156572 AC171004 AJ132693 AJ242919 AJ242920 AJ242921 AJ242922 AJ243030 AJ243031 AJ243032 AJ245385 AJ245386 AJ245387 AJ245388 AJ245389 AJ245390 AK002216 AK149527 BC011480 BC051392 Y11067
GenPept AAH11480 AAH51392 BAB21941 BAE28940 CAA71946 CAB65244 CAB65255 CAB65256 CAB65257 CAB65264 CAB65265 CAB65266 CAB65267 CAB65268 CAB65269 CAB65599 CAB97174 CAB97175 CAB97176
RNA Seq Atlas 14121