Version 5.4
Mus musculus Protein: Tshr
Summary
InnateDB Protein IDBP-161320.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tshr
Protein Name thyroid stimulating hormone receptor
Synonyms AI481368; hypothroid; hyt; pet;
Species Mus musculus
Ensembl Protein ENSMUSP00000021346
InnateDB Gene IDBG-161316 (Tshr)
Protein Structure
UniProt Annotation
Function Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations Note=Defects in Tshr are the cause of hyt/hyt hypothyroidism, an autosomal recessive, fetal-onset, severe hypothyroidism related to TSH hyporesponsiveness and associated with elevated TSH.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004996 thyroid-stimulating hormone receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0008344 adult locomotory behavior
GO:0030183 B cell differentiation
GO:0038194 thyroid-stimulating hormone signaling pathway
GO:0040012 regulation of locomotion
GO:0040018 positive regulation of multicellular organism growth
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID MGI:98849
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002131 Glycoprotein hormone receptor family
IPR002273 Lutropin-choriogonadotropic hormone receptor
IPR002274 Thyrotropin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR00373
PR01144
PR01145
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47750
PhosphoSite PhosphoSite-P47750
TrEMBL
UniProt Splice Variant
Entrez Gene 22095
UniGene Mm.173847
RefSeq NP_035778
MGI ID
MGI Symbol Tshr
OMIM
CCDS CCDS26088
HPRD
IMGT
EMBL AK014519 AK029084 BC086691 BC092523 U02601 U02602
GenPept AAA53209 AAB60455 AAH86691 AAH92523 BAB29408 BAC26286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca