Version 5.4
Mus musculus Gene: Tshr
Summary
InnateDB Gene IDBG-161316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tshr
Gene Name thyroid stimulating hormone receptor
Synonyms AI481368; hypothroid; hyt; pet
Species Mus musculus
Ensembl Gene ENSMUSG00000020963
Encoded Proteins
IDBP-161318
thyroid stimulating hormone receptor
IDBP-161320
thyroid stimulating hormone receptor
IDBP-788076
thyroid stimulating hormone receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165409:
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:91400994-91540509
Strand Forward strand
Band D3
Transcripts
ENSMUST00000021343 ENSMUSP00000021343
ENSMUST00000021346 ENSMUSP00000021346
ENSMUST00000186437 ENSMUSP00000139632
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004996 thyroid-stimulating hormone receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0008344 adult locomotory behavior
GO:0030183 B cell differentiation
GO:0038194 thyroid-stimulating hormone signaling pathway
GO:0040012 regulation of locomotion
GO:0040018 positive regulation of multicellular organism growth
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165409
View Gene Order
ENSBTAG00000017489
Not yet available
Pathways
NETPATH
REACTOME
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_243909
Hormone ligand-binding receptors pathway
REACT_231468
GPCR ligand binding pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu05320
Autoimmune thyroid disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_16942
Hormone ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa05320
Autoimmune thyroid disease pathway
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 22095
UniGene
RefSeq NM_001113404 NM_011648 XM_006515803
OMIM
CCDS CCDS26088 CCDS49135
HPRD
IMGT
MGI ID MGI:98849
MGI Symbol Tshr
EMBL
GenPept
RNA Seq Atlas 22095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca