Mus musculus Gene: Tshr
Summary
InnateDB Gene IDBG-161316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tshr
Gene Name thyroid stimulating hormone receptor
Synonyms AI481368; hypothroid; hyt; pet;
Species Mus musculus
Ensembl Gene ENSMUSG00000020963
Encoded Proteins
thyroid stimulating hormone receptor
thyroid stimulating hormone receptor
thyroid stimulating hormone receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165409:
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:91400994-91540509
Strand Forward strand
Band D3
Transcripts
ENSMUST00000021343 ENSMUSP00000021343
ENSMUST00000021346 ENSMUSP00000021346
ENSMUST00000186437 ENSMUSP00000139632
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004996 thyroid-stimulating hormone receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0008344 adult locomotory behavior
GO:0030183 B cell differentiation
GO:0038194 thyroid-stimulating hormone signaling pathway
GO:0040012 regulation of locomotion
GO:0040018 positive regulation of multicellular organism growth
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Hormone ligand-binding receptors pathway
GPCR ligand binding pathway
Signal Transduction pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Autoimmune thyroid disease pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TSH pathway
REACTOME
G alpha (s) signalling events pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Hormone ligand-binding receptors pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Autoimmune thyroid disease pathway
INOH
PID BIOCARTA
PID NCI
Arf6 trafficking events
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001113404 NM_011648 XM_006515803
OMIM
CCDS CCDS26088 CCDS49135
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas