InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ar

Summary

InnateDB Protein

IDBP-161435.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

androgen receptor

Synonyms

AW320017; Tfm;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052648

InnateDB Gene

IDBG-161433 (Ar)

Protein Structure

UniProt Annotation

Function

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 277 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	277 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004882	androgen receptor activity
GO:0005102	receptor binding
GO:0005496	steroid binding
GO:0005497	androgen binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0050681	androgen receptor binding
GO:0070974	POU domain binding

Biological Process

GO:0001701	in utero embryonic development
GO:0003073	regulation of systemic arterial blood pressure
GO:0003382	epithelial cell morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0009566	fertilization
GO:0009987	cellular process
GO:0010468	regulation of gene expression
GO:0019102	male somatic sex determination
GO:0030521	androgen receptor signaling pathway
GO:0030522	intracellular receptor signaling pathway
GO:0032868	response to insulin
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0033327	Leydig cell differentiation
GO:0035264	multicellular organism growth
GO:0042327	positive regulation of phosphorylation
GO:0043401	steroid hormone mediated signaling pathway
GO:0043410	positive regulation of MAPK cascade
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045720	negative regulation of integrin biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046661	male sex differentiation
GO:0048608	reproductive structure development
GO:0048638	regulation of developmental growth
GO:0048645	organ formation
GO:0048808	male genitalia morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050790	regulation of catalytic activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051259	protein oligomerization
GO:0060520	activation of prostate induction by androgen receptor signaling pathway
GO:0060571	morphogenesis of an epithelial fold
GO:0060599	lateral sprouting involved in mammary gland duct morphogenesis
GO:0060685	regulation of prostatic bud formation
GO:0060736	prostate gland growth
GO:0060740	prostate gland epithelium morphogenesis
GO:0060742	epithelial cell differentiation involved in prostate gland development
GO:0060748	tertiary branching involved in mammary gland duct morphogenesis
GO:0060749	mammary gland alveolus development
GO:0061458	reproductive system development
GO:0071383	cellular response to steroid hormone stimulus
GO:0072520	seminiferous tubule development
GO:0090003	regulation of establishment of protein localization to plasma membrane
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:88064

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001103 Androgen receptor
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF02166
PF00105

PRINTS

PR00521
PR00047

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt