Mus musculus Gene: Ar
Summary
InnateDB Gene IDBG-161433.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ar
Gene Name androgen receptor
Synonyms AW320017; Tfm;
Species Mus musculus
Ensembl Gene ENSMUSG00000046532
Encoded Proteins
androgen receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169083:
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:98149721-98323215
Strand Forward strand
Band C3
Transcripts
ENSMUST00000052837 ENSMUSP00000052648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 277 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 277 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004882 androgen receptor activity
GO:0005102 receptor binding
GO:0005496 steroid binding
GO:0005497 androgen binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0050681 androgen receptor binding
GO:0070974 POU domain binding
Biological Process
GO:0001701 in utero embryonic development
GO:0003073 regulation of systemic arterial blood pressure
GO:0003382 epithelial cell morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0008284 positive regulation of cell proliferation
GO:0008584 male gonad development
GO:0009566 fertilization
GO:0009987 cellular process
GO:0010468 regulation of gene expression
GO:0019102 male somatic sex determination
GO:0030521 androgen receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0032868 response to insulin
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0033327 Leydig cell differentiation
GO:0035264 multicellular organism growth
GO:0042327 positive regulation of phosphorylation
GO:0043401 steroid hormone mediated signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045720 negative regulation of integrin biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046661 male sex differentiation
GO:0048608 reproductive structure development
GO:0048638 regulation of developmental growth
GO:0048645 organ formation
GO:0048808 male genitalia morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050790 regulation of catalytic activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051259 protein oligomerization
GO:0060520 activation of prostate induction by androgen receptor signaling pathway
GO:0060571 morphogenesis of an epithelial fold
GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis
GO:0060685 regulation of prostatic bud formation
GO:0060736 prostate gland growth
GO:0060740 prostate gland epithelium morphogenesis
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0060748 tertiary branching involved in mammary gland duct morphogenesis
GO:0060749 mammary gland alveolus development
GO:0061458 reproductive system development
GO:0071383 cellular response to steroid hormone stimulus
GO:0072520 seminiferous tubule development
GO:0090003 regulation of establishment of protein localization to plasma membrane
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Nuclear Receptor transcription pathway pathway
Gene Expression pathway
Generic Transcription Pathway pathway
KEGG
Oocyte meiosis pathway
Pathways in cancer pathway
Prostate cancer pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Alpha6Beta4Integrin pathway
AndrogenReceptor pathway
TGF_beta_Receptor pathway
IL6 pathway
REACTOME
Nuclear Receptor transcription pathway pathway
Generic Transcription Pathway pathway
Gene Expression pathway
KEGG
Oocyte meiosis pathway
Pathways in cancer pathway
Prostate cancer pathway
INOH
PID BIOCARTA
PID NCI
Nongenotropic Androgen signaling
Coregulation of Androgen receptor activity
Notch-mediated HES/HEY network
Regulation of nuclear beta catenin signaling and target gene transcription
Regulation of nuclear SMAD2/3 signaling
Regulation of Androgen receptor activity
FOXA1 transcription factor network
Cross-References
SwissProt P19091
TrEMBL
UniProt Splice Variant
Entrez Gene 11835
UniGene Mm.39005 Mm.394224 Mm.439657 Mm.475746
RefSeq NM_013476
OMIM
CCDS CCDS30294
HPRD
IMGT
MGI ID MGI:88064
MGI Symbol Ar
EMBL M37890 S56585 X53779 X59592
GenPept AAA37234 AAB19916 CAA37795 CAA42160
RNA Seq Atlas 11835