InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgfbp1

Summary

InnateDB Protein

IDBP-161596.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgfbp1

Protein Name

fibroblast growth factor binding protein 1

Synonyms

FGF-BP; FGF-BP1; FGFBP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056900

InnateDB Gene

IDBG-161594 (Fgfbp1)

Protein Structure

UniProt Annotation

Function

Acts as a carrier protein that releases fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhances the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Extracellular and plasma membrane-associated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in intestine, ovary, lung, placenta and normal and wounded skin. {ECO:0000269PubMed:15806171, ECO:0000269PubMed:9178765}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017134	fibroblast growth factor binding

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

MGI:1096350

InterPro

IPR010510 FGF binding 1

PFAM

PF06473

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O70514

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

14181

UniGene

Mm.46053

RefSeq

NP_032035

MGI ID

MGI Symbol

Fgfbp1

OMIM

CCDS

CCDS19268

HPRD

IMGT

EMBL

AF065441 AK146625 BC065774 U49641

GenPept

AAB05227 AAC17439 AAH65774 BAE27314