InnateDB Protein
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IDBP-161980.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Awat2
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Protein Name
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acyl-CoA wax alcohol acyltransferase 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000033567
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InnateDB Gene
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IDBG-161978 (Awat2)
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Protein Structure
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Function |
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003674
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molecular_function
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GO:0016747
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transferase activity, transferring acyl groups other than amino-acyl groups
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GO:0047196
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long-chain-alcohol O-fatty-acyltransferase activity
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GO:0050252
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retinol O-fatty-acyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3045345
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InterPro |
IPR007130
Diacylglycerol acyltransferase
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PFAM |
PF03982
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6E1M8
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PhosphoSite |
PhosphoSite-
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TrEMBL |
A2ADU0
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UniProt Splice Variant |
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Entrez Gene |
245532
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UniGene |
Mm.118171
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RefSeq |
NP_808414
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MGI ID |
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MGI Symbol |
Awat2
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OMIM |
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CCDS |
CCDS30300
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HPRD |
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IMGT |
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EMBL |
AK034920
AY611031
AY611032
BC138085
BC138086
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GenPept |
AAI38086
AAI38087
AAT68765
AAT68766
BAC28882
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