InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp26a1

Summary

InnateDB Protein

IDBP-162005.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp26a1

Protein Name

cytochrome P450, family 26, subfamily a, polypeptide 1

Synonyms

Cyp26; P450RA; P450RAI; RAH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025946

InnateDB Gene

IDBG-162003 (Cyp26a1)

Protein Structure

UniProt Annotation

Function

Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0005506	iron ion binding
GO:0008401	retinoic acid 4-hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0007417	central nervous system development
GO:0009952	anterior/posterior pattern specification
GO:0014032	neural crest cell development
GO:0034653	retinoic acid catabolic process
GO:0042573	retinoic acid metabolic process
GO:0048384	retinoic acid receptor signaling pathway
GO:0055114	oxidation-reduction process
GO:0071300	cellular response to retinoic acid