Mus musculus Gene: Cyp26a1
Summary
InnateDB Gene IDBG-162003.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyp26a1
Gene Name cytochrome P450, family 26, subfamily a, polypeptide 1
Synonyms Cyp26; P450RA; P450RAI; RAH
Species Mus musculus
Ensembl Gene ENSMUSG00000024987
Encoded Proteins
cytochrome P450, family 26, subfamily a, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095596:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:37697808-37701528
Strand Forward strand
Band C2
Transcripts
ENSMUST00000025946 ENSMUSP00000025946
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0005506 iron ion binding
GO:0008401 retinoic acid 4-hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0007417 central nervous system development
GO:0009952 anterior/posterior pattern specification
GO:0014032 neural crest cell development
GO:0034653 retinoic acid catabolic process
GO:0042573 retinoic acid metabolic process
GO:0048384 retinoic acid receptor signaling pathway
GO:0055114 oxidation-reduction process
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Cytochrome P450 - arranged by substrate type pathway
Phase 1 - Functionalization of compounds pathway
Vitamins pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Retinol metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Vitamins pathway
Cytochrome P450 - arranged by substrate type pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Retinol metabolism pathway
INOH
PID NCI
Cross-References
SwissProt O55127
TrEMBL
UniProt Splice Variant
Entrez Gene 13082
UniGene Mm.42230
RefSeq NM_007811
OMIM
CCDS CCDS29780
HPRD
IMGT
MGI ID MGI:1096359
MGI Symbol Cyp26a1
EMBL AF115769 BC012673 Y12657
GenPept AAD17217 AAH12673 CAA73206
RNA Seq Atlas 13082