InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Qdpr

Summary

InnateDB Protein

IDBP-162285.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Qdpr

Protein Name

quinoid dihydropteridine reductase

Synonyms

2610008L04Rik; D5Ertd371e; Dhpr; PKU2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015950

InnateDB Gene

IDBG-162283 (Qdpr)

Protein Structure

UniProt Annotation

Function

The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004155	6,7-dihydropteridine reductase activity
GO:0016491	oxidoreductase activity
GO:0042803	protein homodimerization activity
GO:0070402	NADPH binding
GO:0070404	NADH binding

Biological Process

GO:0001889	liver development
GO:0006559	L-phenylalanine catabolic process
GO:0006729	tetrahydrobiopterin biosynthetic process
GO:0008152	metabolic process
GO:0010044	response to aluminum ion
GO:0010288	response to lead ion
GO:0033762	response to glucagon
GO:0035690	cellular response to drug
GO:0055114	oxidation-reduction process