Mus musculus Gene: Qdpr
Summary
InnateDB Gene IDBG-162283.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Qdpr
Gene Name quinoid dihydropteridine reductase
Synonyms 2610008L04Rik; D5Ertd371e; Dhpr; PKU2;
Species Mus musculus
Ensembl Gene ENSMUSG00000015806
Encoded Proteins
quinoid dihydropteridine reductase
quinoid dihydropteridine reductase
quinoid dihydropteridine reductase
quinoid dihydropteridine reductase
quinoid dihydropteridine reductase
quinoid dihydropteridine reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151552:
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:45434032-45450235
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000015950 ENSMUSP00000015950
ENSMUST00000117425 ENSMUSP00000112469
ENSMUST00000118097 ENSMUSP00000113958
ENSMUST00000120867 ENSMUSP00000113203
ENSMUST00000149290
ENSMUST00000154962 ENSMUSP00000122081
ENSMUST00000127562 ENSMUSP00000115453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004155 6,7-dihydropteridine reductase activity
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0070402 NADPH binding
GO:0070404 NADH binding
Biological Process
GO:0001889 liver development
GO:0006559 L-phenylalanine catabolic process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0008152 metabolic process
GO:0010044 response to aluminum ion
GO:0010288 response to lead ion
GO:0033762 response to glucagon
GO:0035690 cellular response to drug
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0043005 neuron projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Phenylalanine and tyrosine catabolism pathway
Metabolism pathway
Metabolism of amino acids and derivatives pathway
KEGG
Folate biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Phenylalanine and tyrosine catabolism pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Phenylalanine and tyrosine catabolism pathway
Metabolism pathway
KEGG
Folate biosynthesis pathway
INOH
Folate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.30204 Mm.470971
RefSeq NM_024236
OMIM
CCDS CCDS19272
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas