Homo sapiens Protein: NDE1
InnateDB Protein IDBP-16231.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDE1
Protein Name nudE nuclear distribution gene E homolog 1 (A. nidulans)
Species Homo sapiens
Ensembl Protein ENSP00000345892
InnateDB Gene IDBG-16229 (NDE1)
Protein Structure
UniProt Annotation
Function Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. {ECO:0000269PubMed:17600710, ECO:0000269PubMed:21529752}.
Subcellular Localization Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF- dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis.
Disease Associations Lissencephaly 4 (LIS4) [MIM:614019]: A neurodevelopmental disorder characterized by lissencephaly, severe brain atrophy, extreme microcephaly, and profound mental retardation. {ECO:0000269PubMed:21529751, ECO:0000269PubMed:21529752}. Note=The disease is caused by mutations affecting the gene represented in this entry.Microhydranencephaly (MHAC) [MIM:605013]: A severe neurodevelopmental disorder characterized by microcephaly, severe motor and mental retardation, spasticity, and brain malformations that include gross dilation of the ventricles with complete absence of the cerebral hemispheres or severe delay in their development. {ECO:0000269PubMed:22526350}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum. {ECO:0000269PubMed:21529752}.
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000132 establishment of mitotic spindle orientation
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0021987 cerebral cortex development
GO:0051298 centrosome duplication
GO:0051303 establishment of chromosome localization
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0016020 membrane
GO:0031616 spindle pole centrosome
GO:0032154 cleavage furrow
Protein Structure and Domains
InterPro IPR006964 NUDE protein, C-terminal
PFAM PF04880
Post-translational Modifications
SwissProt Q9NXR1
PhosphoSite PhosphoSite-Q9NXR1
UniProt Splice Variant
Entrez Gene 54820
UniGene Hs.655378
RefSeq XP_005255453
OMIM 609449
HPRD 14815
EMBL AC026401 AF001548 AK000108 BC001421 BC033900 CH471226 KJ534887
GenPept AAH01421 AAH33900 AHW56527 BAA90949 EAW53932