Homo sapiens Gene: NDE1
Summary
InnateDB Gene IDBG-16229.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDE1
Gene Name nudE nuclear distribution E homolog 1 (A. nidulans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072864
Encoded Proteins
nudE nuclear distribution gene E homolog 1 (A. nidulans)
nudE nuclear distribution gene E homolog 1 (A. nidulans)
nudE nuclear distribution gene E homolog 1 (A. nidulans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:15643267-15726353
Strand Forward strand
Band p13.11
Transcripts
ENST00000342673 ENSP00000345892
ENST00000396355 ENSP00000379643
ENST00000396354 ENSP00000379642
ENST00000574109 ENSP00000459875
ENST00000573694 ENSP00000459863
ENST00000570727 ENSP00000459889
ENST00000571896
ENST00000574163
ENST00000572503
ENST00000577101 ENSP00000461729
ENST00000572756 ENSP00000460436
ENST00000576502 ENSP00000461748
ENST00000572967 ENSP00000459918
ENST00000573203 ENSP00000460996
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000132 establishment of mitotic spindle orientation
GO:0000278 mitotic cell cycle
GO:0001764 neuron migration
GO:0007020 microtubule nucleation
GO:0007067 mitotic nuclear division
GO:0007405 neuroblast proliferation
GO:0021987 cerebral cortex development
GO:0030900 forebrain development
GO:0031023 microtubule organizing center organization
GO:0047496 vesicle transport along microtubule
GO:0051298 centrosome duplication
GO:0051303 establishment of chromosome localization
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0016020 membrane
GO:0031616 spindle pole centrosome
GO:0032154 cleavage furrow
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
Separation of Sister Chromatids pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655378
RefSeq NM_001143979 NM_017668 XM_006720898 XM_006725201
HUGO
OMIM
CCDS CCDS10564
HPRD 14815
IMGT
EMBL
GenPept
RNA Seq Atlas