InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NDE1

Summary

InnateDB Gene

IDBG-16229.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDE1

Gene Name

nudE nuclear distribution E homolog 1 (A. nidulans)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000072864

Encoded Proteins

IDBP-16231

nudE nuclear distribution gene E homolog 1 (A. nidulans)

IDBP-237680

nudE nuclear distribution gene E homolog 1 (A. nidulans)

IDBP-237682

nudE nuclear distribution gene E homolog 1 (A. nidulans)

IDBP-754624

IDBP-747910

IDBP-746468

IDBP-749542

IDBP-754237

IDBP-750382

IDBP-750514

IDBP-754379

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:15643267-15726353

Strand

Forward strand

Band

p13.11

Transcripts

ENST00000342673	ENSP00000345892
ENST00000396355	ENSP00000379643
ENST00000396354	ENSP00000379642
ENST00000574109	ENSP00000459875
ENST00000573694	ENSP00000459863
ENST00000570727	ENSP00000459889
ENST00000571896
ENST00000574163
ENST00000572503
ENST00000577101	ENSP00000461729
ENST00000572756	ENSP00000460436
ENST00000576502	ENSP00000461748
ENST00000572967	ENSP00000459918
ENST00000573203	ENSP00000460996

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000132	establishment of mitotic spindle orientation
GO:0000278	mitotic cell cycle
GO:0001764	neuron migration
GO:0007020	microtubule nucleation
GO:0007067	mitotic nuclear division
GO:0007405	neuroblast proliferation
GO:0021987	cerebral cortex development
GO:0030900	forebrain development
GO:0031023	microtubule organizing center organization
GO:0047496	vesicle transport along microtubule
GO:0051298	centrosome duplication
GO:0051303	establishment of chromosome localization

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005829	cytosol
GO:0005874	microtubule
GO:0016020	membrane
GO:0031616	spindle pole centrosome
GO:0032154	cleavage furrow