InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mtap

Summary

InnateDB Protein

IDBP-162826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtap

Protein Name

methylthioadenosine phosphorylase

Synonyms

1300019I21Rik; MSAP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061092

InnateDB Gene

IDBG-162824 (Mtap)

Protein Structure

UniProt Annotation

Function

Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. {ECO:0000255HAMAP-Rule:MF_03155}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000255HAMAP- Rule:MF_03155}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004645	phosphorylase activity
GO:0017061	S-methyl-5-thioadenosine phosphorylase activity

Biological Process

GO:0006166	purine ribonucleoside salvage
GO:0008150	biological_process
GO:0009116	nucleoside metabolic process
GO:0019509	L-methionine biosynthetic process from methylthioadenosine
GO:0033574	response to testosterone