InnateDB Protein
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IDBP-162899.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ggt1
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Protein Name
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gamma-glutamyltransferase 1
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Synonyms
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CD224; dwg; GGT; GGT 1; GGT-1; Ggtp;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000006508
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InnateDB Gene
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IDBG-162897 (Ggt1)
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Protein Structure
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Function |
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Indirectly regulates multiple aspects of skeletal biology. {ECO:0000269PubMed:12810527}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
Note=Defects in Ggt1 are a cause of glutathionuria, severe growth failure, reduced life spans and infertility. Ggt1- deficient mice have multiple metabolic abnormalities and are dwarf. Some abnormalities can be ameliorated by N-acetylcysteine treatment. {ECO:0000269PubMed:12810527, ECO:0000269PubMed:9139708}.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003840
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gamma-glutamyltransferase activity
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GO:0036374
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glutathione hydrolase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:95706
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InterPro |
IPR000101
Gamma-glutamyltranspeptidase
IPR029055
Nucleophile aminohydrolases, N-terminal
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PFAM |
PF01019
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PRINTS |
PR01210
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q60928
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PhosphoSite |
PhosphoSite-Q60928
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TrEMBL |
Q4FK56
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UniProt Splice Variant |
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Entrez Gene |
14598
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UniGene |
Mm.4559
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RefSeq |
NP_032142
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MGI ID |
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MGI Symbol |
Ggt1
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OMIM |
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CCDS |
CCDS23927
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HPRD |
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IMGT |
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EMBL |
AC087540
BC012969
CH466553
CT010196
U30509
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GenPept |
AAA97395
AAH12969
CAJ18404
EDL31902
EDL31903
EDL31904
EDL31905
EDL31906
EDL31907
EDL31908
EDL31909
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