Version 5.4
Mus musculus Gene: Ggt1
Summary
InnateDB Gene IDBG-162897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ggt1
Gene Name gamma-glutamyltransferase 1
Synonyms CD224; dwg; GGT; GGT 1; GGT-1; Ggtp
Species Mus musculus
Ensembl Gene ENSMUSG00000006345
Encoded Proteins
IDBP-162899
gamma-glutamyltransferase 1
IDBP-541520
gamma-glutamyltransferase 1
IDBP-540440
gamma-glutamyltransferase 1
IDBP-532144
gamma-glutamyltransferase 1
IDBP-536493
gamma-glutamyltransferase 1
IDBP-534277
gamma-glutamyltransferase 1
IDBP-542695
gamma-glutamyltransferase 1
IDBP-540398
gamma-glutamyltransferase 1
IDBP-534348
gamma-glutamyltransferase 1
IDBP-538058
gamma-glutamyltransferase 1
IDBP-541724
gamma-glutamyltransferase 1
IDBP-538407
gamma-glutamyltransferase 1
IDBP-538129
gamma-glutamyltransferase 1
IDBP-532499
gamma-glutamyltransferase 1
IDBP-535159
gamma-glutamyltransferase 1
IDBP-537975
gamma-glutamyltransferase 1
IDBP-538184
gamma-glutamyltransferase 1
IDBP-537425
gamma-glutamyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100031:
GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008] The enzyme encoded by this gene catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized and some of which may represent pseudogenes. This gene is classified as type I gamma-glutamyltransferase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]
The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:75561604-75586200
Strand Forward strand
Band C1
Transcripts
ENSMUST00000006508 ENSMUSP00000006508
ENSMUST00000145079 ENSMUSP00000115483
ENSMUST00000140219 ENSMUSP00000118870
ENSMUST00000141062 ENSMUSP00000120686
ENSMUST00000152657 ENSMUSP00000115818
ENSMUST00000129232 ENSMUSP00000115118
ENSMUST00000143792 ENSMUSP00000117851
ENSMUST00000145928 ENSMUSP00000118852
ENSMUST00000131565 ENSMUSP00000119844
ENSMUST00000134503 ENSMUSP00000121312
ENSMUST00000125770 ENSMUSP00000117968
ENSMUST00000128886 ENSMUSP00000118261
ENSMUST00000151212 ENSMUSP00000119387
ENSMUST00000143226 ENSMUSP00000115115
ENSMUST00000124259 ENSMUSP00000122616
ENSMUST00000148447
ENSMUST00000139459 ENSMUSP00000121774
ENSMUST00000129020 ENSMUSP00000118825
ENSMUST00000155186 ENSMUSP00000123017
ENSMUST00000156487
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003840 gamma-glutamyltransferase activity
GO:0036374 glutathione hydrolase activity
Biological Process
GO:0002682 regulation of immune system process
GO:0006508 proteolysis
GO:0006536 glutamate metabolic process
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006751 glutathione catabolic process
GO:0007283 spermatogenesis
GO:0019344 cysteine biosynthetic process
GO:0031638 zymogen activation
GO:0050727 regulation of inflammatory response
GO:0060427 lung connective tissue development
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0031988 membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100031
View Gene Order
ENSBTAG00000046900
Not yet available
Pathways
NETPATH
REACTOME
REACT_237136
Aflatoxin activation and detoxification pathway
REACT_243247
Phase II conjugation pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_215316
Glutathione conjugation pathway
REACT_210980
Glutathione synthesis and recycling pathway
REACT_232343
Biological oxidations pathway
REACT_188625
Arachidonic acid metabolism pathway
REACT_215561
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
KEGG
mmu00480
Glutathione metabolism pathway
mmu00590
Arachidonic acid metabolism pathway
mmu00430
Taurine and hypotaurine metabolism pathway
mmu00460
Cyanoamino acid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150420
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_6960
Glutathione synthesis and recycling pathway
REACT_6926
Glutathione conjugation pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_228214
Aflatoxin activation and detoxification pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
hsa00460
Cyanoamino acid metabolism pathway
hsa00430
Taurine and hypotaurine metabolism pathway
hsa00480
Glutathione metabolism pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 14598
UniGene Mm.4559
RefSeq NM_008116 XM_006513230 XM_006513231 XM_006513232
OMIM
CCDS CCDS23927
HPRD
IMGT
MGI ID MGI:95706
MGI Symbol Ggt1
EMBL
GenPept
RNA Seq Atlas 14598

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca