InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hspa5

Summary

InnateDB Protein

IDBP-163155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspa5

Protein Name

heat shock protein 5

Synonyms

AL022860; AU019543; baffled; Bip; D2Wsu141e; D2Wsu17e; Grp78; Hsce70; mBiP; SEZ-7; Sez7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097747

InnateDB Gene

IDBG-163151 (Hspa5)

Protein Structure

UniProt Annotation

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138, ECO:0000269PubMed:21992152}. Melanosome {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:21992152}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 216 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	216 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0031625	ubiquitin protein ligase binding
GO:0043022	ribosome binding
GO:0051082	unfolded protein binding
GO:0051787	misfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006983	ER overload response
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0021589	cerebellum structural organization
GO:0021680	cerebellar Purkinje cell layer development
GO:0021762	substantia nigra development
GO:0030335	positive regulation of cell migration
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031398	positive regulation of protein ubiquitination
GO:0034976	response to endoplasmic reticulum stress
GO:0035437	maintenance of protein localization in endoplasmic reticulum
GO:0040019	positive regulation of embryonic development
GO:0042149	cellular response to glucose starvation
GO:0043066	negative regulation of apoptotic process
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0071236	cellular response to antibiotic
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005790	smooth endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0008180	COP9 signalosome
GO:0009986	cell surface
GO:0016020	membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0030496	midbody
GO:0034663	endoplasmic reticulum chaperone complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95835

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20029