Version 5.4
Mus musculus Protein: Il18
Summary
InnateDB Protein IDBP-163504.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il18
Protein Name interleukin 18
Synonyms Igif; Il-18;
Species Mus musculus
Ensembl Protein ENSMUSP00000054591
InnateDB Gene IDBG-163502 (Il18)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 5 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0010628 positive regulation of gene expression
GO:0030101 natural killer cell activation
GO:0030155 regulation of cell adhesion
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032740 positive regulation of interleukin-17 production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0042088 T-helper 1 type immune response
GO:0042104 positive regulation of activated T cell proliferation
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0045087 innate immune response (InnateDB)
GO:0051142 positive regulation of NK T cell proliferation
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:107936
InterPro IPR000975 Interleukin-1 family
IPR008996 Cytokine, IL-1-like
IPR015529 Interleukin-18
PFAM PF00340
PRINTS PR00264
PR01933
PIRSF PIRSF015162
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL K3W4N2
UniProt Splice Variant
Entrez Gene 16173
UniGene
RefSeq
MGI ID
MGI Symbol Il18
OMIM
CCDS
HPRD
IMGT
EMBL AC025500
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca