InnateDB Protein
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IDBP-163738.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Efna1
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Protein Name
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ephrin A1
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Synonyms
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AI325262; B61; Efl1; Epl1; Eplg1; Lerk1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000029566
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InnateDB Gene
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IDBG-163736 (Efna1)
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Protein Structure
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Function |
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269PubMed:16782872, ECO:0000269PubMed:17143272, ECO:0000269PubMed:18387945}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.Ephrin-A1, secreted form: Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:103236
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InterPro |
IPR001799
Ephrin
IPR008972
Cupredoxin
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PFAM |
PF00812
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PRINTS |
PR01347
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P52793
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PhosphoSite |
PhosphoSite-P52793
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TrEMBL |
D3YTT5
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UniProt Splice Variant |
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Entrez Gene |
13636
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UniGene |
Mm.15675
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RefSeq |
NP_034237
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MGI ID |
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MGI Symbol |
Efna1
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OMIM |
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CCDS |
CCDS17501
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HPRD |
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IMGT |
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EMBL |
AC132327
BC002046
D38146
U26188
U90662
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GenPept |
AAA67563
AAB50237
AAH02046
BAA07344
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