InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Derl3

Summary

InnateDB Protein

IDBP-163984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Derl3

Protein Name

Der1-like domain family, member 3

Synonyms

1810006I20Rik; 1810063P04Rik; derlin-3; IZP6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009236

InnateDB Gene

IDBG-163982 (Derl3)

Protein Structure

UniProt Annotation

Function

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in spleen, lung, liver, spleen and testis. Expressed at intermediate level in kidney. Weakly or not expressed in brain, heart and skeletal muscle. {ECO:0000269PubMed:11422294}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0018279	protein N-linked glycosylation via asparagine
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response