InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pvrl3

Summary

InnateDB Protein

IDBP-164002.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pvrl3

Protein Name

poliovirus receptor-related 3

Synonyms

2610301B19Rik; 3000002N23Rik; 4921513D19Rik; AA407785; AU016832; AW538082; CD113;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093757

InnateDB Gene

IDBG-163998 (Pvrl3)

Protein Structure

UniProt Annotation

Function

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269PubMed:10744716, ECO:0000269PubMed:11827984, ECO:0000269PubMed:12121624, ECO:0000269PubMed:12558799, ECO:0000269PubMed:16128743}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269PubMed:11827984}.

Disease Associations

Tissue Specificity

Ubiquitous with high expression in testes. Localized in spermatids at Sertoli-spermatid junctions. Expressed in ovarian granulosa cells, but only faintly expressed after ovulation. {ECO:0000269PubMed:10744716, ECO:0000269PubMed:12121624}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002089	lens morphogenesis in camera-type eye
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0009566	fertilization
GO:0016337	single organismal cell-cell adhesion
GO:0060042	retina morphogenesis in camera-type eye

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005913	cell-cell adherens junction
GO:0016021	integral component of membrane
GO:0043296	apical junction complex
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1930171

InterPro

IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF07686
PF08205

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JLB9