Version 5.4
Mus musculus Gene: Pvrl3
Summary
InnateDB Gene IDBG-163998.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pvrl3
Gene Name poliovirus receptor-related 3
Synonyms 2610301B19Rik; 3000002N23Rik; 4921513D19Rik; AA407785; AU016832; AW538082; CD113
Species Mus musculus
Ensembl Gene ENSMUSG00000022656
Encoded Proteins
IDBP-164000
poliovirus receptor-related 3
IDBP-164002
poliovirus receptor-related 3
IDBP-164004
poliovirus receptor-related 3
IDBP-401078
poliovirus receptor-related 3
IDBP-401077
poliovirus receptor-related 3
IDBP-401076
poliovirus receptor-related 3
IDBP-533716
poliovirus receptor-related 3
IDBP-536941
poliovirus receptor-related 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177707:
This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:46387706-46498525
Strand Reverse strand
Band B5
Transcripts
ENSMUST00000023335 ENSMUSP00000023335
ENSMUST00000096052 ENSMUSP00000093757
ENSMUST00000023334 ENSMUSP00000023334
ENSMUST00000121245 ENSMUSP00000113146
ENSMUST00000121803 ENSMUSP00000112567
ENSMUST00000119941 ENSMUSP00000113301
ENSMUST00000124602 ENSMUSP00000115927
ENSMUST00000132089
ENSMUST00000149901 ENSMUSP00000117479
ENSMUST00000133935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0002089 lens morphogenesis in camera-type eye
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0009566 fertilization
GO:0016337 single organismal cell-cell adhesion
GO:0060042 retina morphogenesis in camera-type eye
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005913 cell-cell adherens junction
GO:0016021 integral component of membrane
GO:0043296 apical junction complex
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000177707
View Gene Order
ENSBTAG00000013769
Not yet available
Pathways
NETPATH
REACTOME
REACT_248094
Cell-cell junction organization pathway
REACT_230395
Adherens junctions interactions pathway
REACT_245004
Nectin/Necl trans heterodimerization pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04520
Adherens junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19268
Nectin/Necl trans heterodimerization pathway
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04520
Adherens junction pathway
INOH
PID NCI
nectin_pathway
Nectin adhesion pathway
Cross-References
SwissProt Q9JLB9
TrEMBL
UniProt Splice Variant
Entrez Gene 58998
UniGene Mm.328072 Mm.394774 Mm.40477
RefSeq NM_021497 NM_021495 NM_021496 XM_006522434 XM_006522435 XM_006522436
OMIM
CCDS CCDS28205 CCDS28204 CCDS28206
HPRD
IMGT
MGI ID MGI:1930171
MGI Symbol Pvrl3
EMBL AF195833 AF195834 AF195835 AK011949 BC125588 BC132187
GenPept AAF63685 AAF63686 AAF63687 AAI25589 AAI32188 BAB27933
RNA Seq Atlas 58998

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca