Mus musculus Gene: Pvrl3
Summary
InnateDB Gene IDBG-163998.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pvrl3
Gene Name poliovirus receptor-related 3
Synonyms 2610301B19Rik; 3000002N23Rik; 4921513D19Rik; AA407785; AU016832; AW538082; CD113;
Species Mus musculus
Ensembl Gene ENSMUSG00000022656
Encoded Proteins
poliovirus receptor-related 3
poliovirus receptor-related 3
poliovirus receptor-related 3
poliovirus receptor-related 3
poliovirus receptor-related 3
poliovirus receptor-related 3
poliovirus receptor-related 3
poliovirus receptor-related 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177707:
This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:46387706-46498525
Strand Reverse strand
Band B5
Transcripts
ENSMUST00000023335 ENSMUSP00000023335
ENSMUST00000096052 ENSMUSP00000093757
ENSMUST00000023334 ENSMUSP00000023334
ENSMUST00000121245 ENSMUSP00000113146
ENSMUST00000121803 ENSMUSP00000112567
ENSMUST00000119941 ENSMUSP00000113301
ENSMUST00000124602 ENSMUSP00000115927
ENSMUST00000132089
ENSMUST00000149901 ENSMUSP00000117479
ENSMUST00000133935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0002089 lens morphogenesis in camera-type eye
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0009566 fertilization
GO:0016337 single organismal cell-cell adhesion
GO:0060042 retina morphogenesis in camera-type eye
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005913 cell-cell adherens junction
GO:0016021 integral component of membrane
GO:0043296 apical junction complex
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell-cell junction organization pathway
Adherens junctions interactions pathway
Nectin/Necl trans heterodimerization pathway
Cell junction organization pathway
Cell-Cell communication pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Adherens junction pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Nectin/Necl trans heterodimerization pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
Adherens junctions interactions pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Adherens junction pathway
INOH
PID BIOCARTA
PID NCI
Nectin adhesion pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.328072 Mm.394774 Mm.40477
RefSeq NM_021495 NM_021496 NM_021497 XM_006522434 XM_006522435 XM_006522436
OMIM
CCDS CCDS28204 CCDS28205 CCDS28206
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas