InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slu7

Summary

InnateDB Protein

IDBP-164066.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slu7

Protein Name

SLU7 splicing factor homolog (S. cerevisiae)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020681

InnateDB Gene

IDBG-164064 (Slu7)

Protein Structure

UniProt Annotation

Function

Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000386	second spliceosomal transesterification activity
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0030628	pre-mRNA 3'-splice site binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0000380	alternative mRNA splicing, via spliceosome
GO:0000389	mRNA 3'-splice site recognition
GO:0006886	intracellular protein transport
GO:0034605	cellular response to heat

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0030532	small nuclear ribonucleoprotein complex
GO:0043231	intracellular membrane-bounded organelle
GO:0071013	catalytic step 2 spliceosome