InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adcy2

Summary

InnateDB Protein

IDBP-164685.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adcy2

Protein Name

adenylate cyclase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022013

InnateDB Gene

IDBG-164683 (Adcy2)

Protein Structure

UniProt Annotation

Function

This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004016	adenylate cyclase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008179	adenylate cyclase binding
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity
GO:0016849	phosphorus-oxygen lyase activity
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006171	cAMP biosynthetic process
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0043234	protein complex
GO:0045121	membrane raft