Version 5.4
Mus musculus Protein: Pmvk
Summary
InnateDB Protein IDBP-164715.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pmvk
Protein Name phosphomevalonate kinase
Synonyms 1110011E12Rik; 2900002L22Rik; AV001327; PMK; PMKA; PMKASE;
Species Mus musculus
Ensembl Protein ENSMUSP00000029564
InnateDB Gene IDBG-164713 (Pmvk)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Peroxisome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004631 phosphomevalonate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0016126 sterol biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0070723 response to cholesterol
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1915853
InterPro IPR005919 Higher eukaryotic phosphomevalonate kinase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF04275
PRINTS
PIRSF PIRSF036639
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D1G2
PhosphoSite PhosphoSite-Q9D1G2
TrEMBL
UniProt Splice Variant
Entrez Gene 68603
UniGene Mm.34242
RefSeq NP_081060
MGI ID
MGI Symbol Pmvk
OMIM
CCDS CCDS17511
HPRD
IMGT
EMBL AK003607 AK013477 BC028659
GenPept AAH28659 BAB22886 BAB28875

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca