Mus musculus Gene: Pmvk
Summary
InnateDB Gene IDBG-164713.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pmvk
Gene Name phosphomevalonate kinase
Synonyms 1110011E12Rik; 2900002L22Rik; AV001327; PMK; PMKA; PMKASE;
Species Mus musculus
Ensembl Gene ENSMUSG00000027952
Encoded Proteins
phosphomevalonate kinase
phosphomevalonate kinase
phosphomevalonate kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163344:
This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:89459118-89469013
Strand Forward strand
Band F1
Transcripts
ENSMUST00000029564 ENSMUSP00000029564
ENSMUST00000107410 ENSMUSP00000103033
ENSMUST00000184515 ENSMUSP00000139116
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004631 phosphomevalonate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0016126 sterol biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0070723 response to cholesterol
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Activation of gene expression by SREBF (SREBP) pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Cholesterol biosynthesis pathway
KEGG
Terpenoid backbone biosynthesis pathway
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
Cholesterol biosynthesis pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Metabolism pathway
KEGG
Terpenoid backbone biosynthesis pathway
Peroxisome pathway
INOH
Steroids metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.34242
RefSeq NM_026784 NM_027348
OMIM
CCDS CCDS17511 CCDS71270
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas