InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: U2af1

Summary

InnateDB Protein

IDBP-164739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

U2af1

Protein Name

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1

Synonyms

2010107D16Rik; 35kDa;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014684

InnateDB Gene

IDBG-164737 (U2af1)

Protein Structure

UniProt Annotation

Function

Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18758164}. Nucleus speckle {ECO:0000269PubMed:18758164}.

Disease Associations

Tissue Specificity

Expressed in primary spermatocytes and elongating spermatids (at protein level). {ECO:0000269PubMed:18758164}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0050733	RS domain binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0016607	nuclear speck
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

MGI:98884

InterPro

IPR000504 RNA recognition motif domain
IPR000571 Zinc finger, CCCH-type
IPR003954 RNA recognition motif domain, eukaryote
IPR009145 U2 auxiliary factor small subunit

PFAM

PF00076
PF00642

PRINTS

PR01848

PIRSF

SMART

SM00360
SM00356
SM00361

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt