Mus musculus Protein: Gm11808 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-165032.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Gm11808 | ||||||||||
Protein Name | predicted gene 11808 | ||||||||||
Synonyms | |||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000086852 | ||||||||||
InnateDB Gene | IDBG-165030 (Gm11808) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269PubMed:19754430}.60S ribosomal protein L40: Component of the 60S subunit of the ribosome. {ECO:0000269PubMed:19754430}. | ||||||||||
Subcellular Localization | Ubiquitin: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.60S ribosomal protein L40: Cytoplasm {ECO:0000250}. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | |||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:3649356 | ||||||||||
InterPro |
IPR000626
Ubiquitin-like IPR001975 Ribosomal protein L40e IPR019956 Ubiquitin IPR022617 Rad60/SUMO-like domain IPR029071 Ubiquitin-related domain |
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PFAM |
PF00240
PF14560 PF01020 PF11976 |
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PRINTS |
PR00348
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PIRSF | |||||||||||
SMART |
SM00213
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | P62984 | ||||||||||
PhosphoSite | PhosphoSite-P62984 | ||||||||||
TrEMBL | Q66JP1 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 22186 | ||||||||||
UniGene | |||||||||||
RefSeq | |||||||||||
MGI ID | 3VHT | ||||||||||
MGI Symbol | Gm11808 | ||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AC157774 AF118402 AK018726 BC014772 BC054413 BC080838 BC086924 BC087922 CH466538 CH466569 EF437347 EF580991 | ||||||||||
GenPept | AAD14688 AAH14772 AAH54413 AAH80838 AAH86924 AAH87922 ABQ52426 ABS83516 BAB31371 EDL05703 EDL28828 EDL28829 EDL28830 EDL28831 EDL28832 EDL28833 EDL28834 | ||||||||||