InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fn1

Summary

InnateDB Protein

IDBP-165051.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fn1

Protein Name

fibronectin 1

Synonyms

E330027I09; Fn; Fn-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054499

InnateDB Gene

IDBG-165049 (Fn1)

Protein Structure

UniProt Annotation

Function

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. {ECO:0000269PubMed:21768292}.Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 641 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	641 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016504	peptidase activator activity

Biological Process

GO:0001525	angiogenesis
GO:0006953	acute-phase response
GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007161	calcium-independent cell-matrix adhesion
GO:0008360	regulation of cell shape
GO:0010952	positive regulation of peptidase activity
GO:0018149	peptide cross-linking
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042060	wound healing
GO:0045773	positive regulation of axon extension

Cellular Component

GO:0005576	extracellular region
GO:0005577	fibrinogen complex
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005615	extracellular space
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0016324	apical plasma membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle