Mus musculus Protein: Irx1
Summary
InnateDB Protein IDBP-165336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irx1
Protein Name Iroquois related homeobox 1 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000076562
InnateDB Gene IDBG-165334 (Irx1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in specific and overlapping patterns with Irx1 and Irx2 in the developing and adult metanephric kidney. In the adult metanephros, renal expression is found in the loop of Henle in the S3 proximal tubule segment and in the thick ascending limb (TAL) of the distal tubule. {ECO:0000269PubMed:17875669}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001656 metanephros development
GO:0006355 regulation of transcription, DNA-templated
GO:0072086 specification of loop of Henle identity
GO:0072272 proximal/distal pattern formation involved in metanephric nephron development
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1197515
InterPro IPR001356 Homeobox domain
IPR003893 Iroquois-class homeodomain protein
IPR009057 Homeodomain-like
PFAM PF00046
PRINTS
PIRSF
SMART SM00389
SM00548
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P81068
PhosphoSite PhosphoSite-P81068
TrEMBL
UniProt Splice Variant
Entrez Gene 16371
UniGene Mm.402685
RefSeq NP_034703
MGI ID
MGI Symbol Irx1
OMIM
CCDS CCDS26627
HPRD
IMGT
EMBL AF165984 AK133937 CH466563 CT009684 Y15002
GenPept AAF63954 BAE21938 CAA75234 EDL37041