Mus musculus Protein: Antxr1 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-165519.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Antxr1 | ||||||||||||||
Protein Name | anthrax toxin receptor 1 | ||||||||||||||
Synonyms | 2310008J16Rik; 2810405N18Rik; Antrx1; Tem8; | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000045634 | ||||||||||||||
InnateDB Gene | IDBG-165517 (Antxr1) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells (By similarity). {ECO:0000250}. | ||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, filopodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=At the membrane of lamellipodia and at the tip of actin- enriched filopodia. Colocalizes with actin at the base of lamellipodia (By similarity). {ECO:0000250}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:1916788 | ||||||||||||||
InterPro |
IPR002035
von Willebrand factor, type A IPR008399 Anthrax toxin receptor, C-terminal IPR008400 Anthrax toxin receptor, extracellular IPR017360 Anthrax toxin receptor |
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PFAM |
PF00092
PF05586 PF05587 |
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PRINTS | |||||||||||||||
PIRSF |
PIRSF038023
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SMART |
SM00327
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q9CZ52 | ||||||||||||||
PhosphoSite | PhosphoSite-Q9CZ52 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 69538 | ||||||||||||||
UniGene | Mm.398192 | ||||||||||||||
RefSeq | NP_473382 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Antxr1 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS20318 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AF378762 AK013005 BC094544 | ||||||||||||||
GenPept | AAH94544 AAL11999 BAB28591 | ||||||||||||||