InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lgmn

Summary

InnateDB Protein

IDBP-165746.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lgmn

Protein Name

legumain

Synonyms

AEP; AI746452; AU022324; Prsc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021607

InnateDB Gene

IDBG-165744 (Lgmn)

Protein Structure

UniProt Annotation

Function

Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. {ECO:0000269PubMed:17350006, ECO:0000269PubMed:21292981, ECO:0000269PubMed:24407422, ECO:0000269PubMed:9742219}.

Subcellular Localization

Lysosome {ECO:0000269PubMed:21292981, ECO:0000269PubMed:9742219}.

Disease Associations

Tissue Specificity

Detected in kidney proximal tubules (at protein level). Ubiquitous. Particularly abundant in kidney and placenta. {ECO:0000269PubMed:21292981, ECO:0000269PubMed:9742219}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0008233	peptidase activity

Biological Process

GO:0003014	renal system process
GO:0006508	proteolysis
GO:0010447	response to acidity
GO:0032801	receptor catabolic process
GO:0040015	negative regulation of multicellular organism growth
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:1901185	negative regulation of ERBB signaling pathway