Mus musculus Gene: Lgmn
Summary
InnateDB Gene IDBG-165744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lgmn
Gene Name legumain
Synonyms AEP; AI746452; AU022324; Prsc1;
Species Mus musculus
Ensembl Gene ENSMUSG00000021190
Encoded Proteins
legumain
legumain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Lgmn is an asparagine endopeptidase that removes the majority of the Tlr9 ectodomain, and this catalytic cleavage is required for Tlr9 endolysosome signalling in response to DNA.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] LGMN is an asparagine endopeptidase that removes the majority of the TLR9 ectodomain, and this catalytic cleavage is required for TLR9 endolysosome signalling in response to DNA. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100600:
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:102394084-102439813
Strand Reverse strand
Band E
Transcripts
ENSMUST00000021607 ENSMUSP00000021607
ENSMUST00000110020 ENSMUSP00000105647
ENSMUST00000146499
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008233 peptidase activity
Biological Process
GO:0003014 renal system process
GO:0006508 proteolysis
GO:0010447 response to acidity
GO:0032801 receptor catabolic process
GO:0040015 negative regulation of multicellular organism growth
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:1901185 negative regulation of ERBB signaling pathway
Cellular Component
GO:0005764 lysosome
GO:0005770 late endosome
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Trafficking and processing of endosomal TLR pathway
Vitamin D (calciferol) metabolism pathway
Metabolism pathway
Immune System pathway
Metabolism of lipids and lipoproteins pathway
MHC class II antigen presentation pathway
Toll-Like Receptors Cascades pathway
Adaptive Immune System pathway
Metabolism of steroid hormones and vitamin D pathway
KEGG
Lysosome pathway
Antigen processing and presentation pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
MHC class II antigen presentation pathway
Metabolism of lipids and lipoproteins pathway
Innate Immune System pathway
Metabolism of steroid hormones and vitamin D pathway
Toll-Like Receptors Cascades pathway
Adaptive Immune System pathway
Immune System pathway
Trafficking and processing of endosomal TLR pathway
Vitamin D (calciferol) metabolism pathway
Metabolism pathway
Trafficking and processing of endosomal TLR pathway
Immune System pathway
Toll-Like Receptors Cascades pathway
MHC class II antigen presentation pathway
Metabolism of lipids and lipoproteins pathway
Vitamin D (calciferol) metabolism pathway
Metabolism of steroid hormones and vitamin D pathway
Metabolism pathway
Adaptive Immune System pathway
Innate Immune System pathway
KEGG
Lysosome pathway
Antigen processing and presentation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O89017
TrEMBL A2RTI3 Q3UE99
UniProt Splice Variant
Entrez Gene 19141
UniGene Mm.17185 Mm.471878
RefSeq NM_011175 XM_006515604
OMIM
CCDS CCDS26119
HPRD
IMGT
MGI ID MGI:1330838
MGI Symbol Lgmn
EMBL AF044266 AJ000990 AK149666 BC132515 BC132519 CH466549
GenPept AAF21659 AAI32516 AAI32520 BAE29012 CAA04439 EDL18865
RNA Seq Atlas 19141