InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lgmn

Summary

InnateDB Gene

IDBG-165744.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lgmn

Gene Name

legumain

Synonyms

AEP; AI746452; AU022324; Prsc1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021190

Encoded Proteins

IDBP-165746

legumain

IDBP-261155

legumain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21402738

Lgmn is an asparagine endopeptidase that removes the majority of the Tlr9 ectodomain, and this catalytic cleavage is required for Tlr9 endolysosome signalling in response to DNA.

InnateDB Annotation from Orthologs

Summary

PMID 21402738

[Homo sapiens] LGMN is an asparagine endopeptidase that removes the majority of the TLR9 ectodomain, and this catalytic cleavage is required for TLR9 endolysosome signalling in response to DNA. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100600:
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:102394084-102439813

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021607	ENSMUSP00000021607
ENSMUST00000110020	ENSMUSP00000105647
ENSMUST00000146499

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0008233	peptidase activity

Biological Process

GO:0003014	renal system process
GO:0006508	proteolysis
GO:0010447	response to acidity
GO:0032801	receptor catabolic process
GO:0040015	negative regulation of multicellular organism growth
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:1901185	negative regulation of ERBB signaling pathway