Version 5.4
Mus musculus Protein: Lss
Summary
InnateDB Protein IDBP-165749.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lss
Protein Name lanosterol synthase
Synonyms 2810025N20Rik; BC029082; D10Ertd116e; Osc;
Species Mus musculus
Ensembl Protein ENSMUSP00000046856
InnateDB Gene IDBG-165747 (Lss)
Protein Structure
UniProt Annotation
Function Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. {ECO:0000250UniProtKB:P48450}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000250 lanosterol synthase activity
GO:0003824 catalytic activity
GO:0016866 intramolecular transferase activity
Biological Process
GO:0006695 cholesterol biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid particle
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1336155
InterPro IPR001330 Prenyltransferase/squalene oxidase
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR018333 Squalene cyclase
PFAM PF00432
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BLN5
PhosphoSite PhosphoSite-Q8BLN5
TrEMBL
UniProt Splice Variant
Entrez Gene 16987
UniGene Mm.55075
RefSeq NP_666118
MGI ID
MGI Symbol Lss
OMIM
CCDS CCDS23948
HPRD
IMGT
EMBL AK044016 AK078023 BC029082
GenPept AAH29082 BAC31739 BAC37102

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca