Version 5.4
Mus musculus Gene: Lss
Summary
InnateDB Gene IDBG-165747.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lss
Gene Name lanosterol synthase
Synonyms 2810025N20Rik; BC029082; D10Ertd116e; Osc
Species Mus musculus
Ensembl Gene ENSMUSG00000033105
Encoded Proteins
IDBP-165749
lanosterol synthase
IDBP-538288
lanosterol synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160285:
The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:76531588-76557138
Strand Forward strand
Band C1
Transcripts
ENSMUST00000048678 ENSMUSP00000046856
ENSMUST00000159013
ENSMUST00000162475
ENSMUST00000160671
ENSMUST00000159172
ENSMUST00000163049 ENSMUSP00000125575
ENSMUST00000162848
ENSMUST00000162282
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000250 lanosterol synthase activity
GO:0003824 catalytic activity
GO:0016866 intramolecular transferase activity
Biological Process
GO:0006695 cholesterol biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid particle
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160285
View Gene Order
ENSBTAG00000018936
Not yet available
Pathways
NETPATH
REACTOME
REACT_198969
Activation of gene expression by SREBF (SREBP) pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_208531
Cholesterol biosynthesis pathway
KEGG
mmu00100
Steroid biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_9405
Cholesterol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00100
Steroid biosynthesis pathway
INOH
INOH website
Steroids metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.55075
RefSeq NM_146006 XM_006513283
OMIM
CCDS CCDS23948
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca